2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W549985
    Oleoyl-L-carnitine chloride 31062-78-9 98%
    Oleoyl-L-carnitine (chloride) is an active compound and can be used for the research of analytical study.
    Oleoyl-L-carnitine chloride
  • HY-W554764
    Cyclo(-asp-gly) 52661-97-9 98%
    Cyclo(-asp-gly) is a cyclic dipeptide composed of amino acids and is a potential TRPV1 stimulator.
    Cyclo(-asp-gly)
  • HY-W573558
    (tert-Butoxycarbonyl)-DL-glutamine 85535-45-1 98%
    (tert-Butoxycarbonyl)-DL-glutamine (Compound 2I) is a tert-butoxycarbonyl-protected glutamine derivative. (tert-Butoxycarbonyl)-DL-glutamine can be used for the synthesis of N-BOC-L-glutamine esters and Apocynin (HY-N0088). (tert-Butoxycarbonyl)-DL-glutamine is applicable to the research of retinal degenerative diseases.
    (tert-Butoxycarbonyl)-DL-glutamine
  • HY-W580812
    (R)-3-Aminopyrrolidine-2,5-dione 404887-22-5 98%
    (R)-3-Aminopyrrolidine-2,5-dione is a potential anticonvulsant agent and its derivatives have comparable in vivo efficacy.
    (R)-3-Aminopyrrolidine-2,5-dione
  • HY-W580836
    (S)-3-Aminopyrrolidine-2,5-dione 73537-92-5 98%
    (S)-3-Aminopyrrolidine-2,5-dione is a potential anticonvulsant agent and its derivatives have comparable in vivo potency.
    (S)-3-Aminopyrrolidine-2,5-dione
  • HY-W585928
    Di-o-cresyl phosphate 35787-74-7 98%
    Di-o-cresyl phosphate is a urinary metabolite of tri-o-cresyl phosphate (HY-W011086), o,o,m-tricresyl phosphate, and o,o,p-tricresyl phosphate, and serves as a biomarker for monitoring exposure to ortho-isomers of tricresyl phosphate. Di-o-cresyl phosphate is not a metabolite of mono-o-tricresyl phosphate. Di-o-cresyl phosphate can be used in studies related to delayed neuropathy (OPIDN).
    Di-o-cresyl phosphate
  • HY-W587743
    N1-Acetyl-5-methoxykynuramine hydrochloride 1215711-91-3 98%
    N1-Acetyl-5-methoxykynuramine (AMK) hydrochloride is an active metabolite of the neurohormone melatonin (HY-B0075). N1-Acetyl-5-methoxykynuramine hydrochloride (200 µM) effectively scavenges singlet oxygen (ROS).1 It also inhibits the production of prostaglandin E2 (PGE2) and prostaglandin D2 (PGD2) induced by epinephrine and arachidonic acid in a concentration- and time-dependent manner, and suppresses the increase in COX-2 levels induced by LPS (HY-D1056) in RAW 264.7 macrophages at a concentration of 500 µM. In a mouse model of Parkinson's disease induced by MPTP (HY-15608), N1-Acetyl-5-methoxykynuramine hydrochloride (20 mg/kg) reduces the increase in lipid peroxidation in the cytosol and mitochondria of the substantia nigra and striatum. N1-Acetyl-5-methoxykynuramine hydrochloride can be used in research on metabolic and neurological diseases
    N1-Acetyl-5-methoxykynuramine hydrochloride
  • HY-W587807
    11-cis-Retinol 22737-96-8 98%
    11-cis-Retinol, a form of retinol, can bind to RDH5. 11-cis-Retinol promote dark adaptation and recovery of photoresponsiveness of red cones but not of red rods.
    11-cis-Retinol
  • HY-W588203
    β-Nornicotyrine 494-98-4 98%
    β-Nornicotyrine (3-(1H-Pyrrol-2-yl)pyridine) is an alkaloid that has been found in N. tabacum. β-Nornicotyrine can be used for research on neurological diseases.
    β-Nornicotyrine
  • HY-W590845
    Ethyl (E)-ferulate 28028-62-8 98%
    Ethyl (E)-ferulate is an AMPK/Nrf2 signaling pathway activator that can reduce lipopolysaccharide (HY-D1056)-induced acute lung injury. Additionally, Ethyl (E)-ferulate exhibits free radical scavenging properties, providing anti-inflammatory, antioxidant, neuroprotective, and sunscreen effects. Ethyl (E)-ferulate holds promise for research in the fields of inflammation and neurodegenerative diseases.
    Ethyl (E)-ferulate
  • HY-W611212
    1-(3-Fluorophenyl)propan-2-one 1737-19-5 98%
    1-(3-Fluorophenyl)propan-2-one is a precursor in the synthesis of amphetamines.
    1-(3-Fluorophenyl)propan-2-one
  • HY-W615141
    Desmethyltrimipramine 2293-21-2 98.03%
    Desmethyltrimipramine (DTRI) is a metabolite of Trimipramine (HY-B1213A) (a 5-HT receptor antagonist and antidepressant).
    Desmethyltrimipramine
  • HY-W644305
    Androst-16-en-3-ol 7148-51-8 98%
    Androst-16-en-3-ol is a pheromone derived from boars that triggers mating responses in estrous sows. It also exists in human urine, plasma, saliva and sweat. As an endogenous neurosteroid, Androst-16-en-3-ol acts as a positive allosteric modulator of GABAA receptors (GABAA receptor) and exerts anxiolytic, antidepressant and anticonvulsant activities in mice.
    Androst-16-en-3-ol
  • HY-W653762
    Cetirizine N-oxide 1076199-80-8 98%
    Cetirizine N-oxide is an oxidative degradation product of the histamine H1 receptor antagonist Cetirizine (HY-17042).
    Cetirizine N-oxide
  • HY-W653803
    Lamotrigine N2-Oxide 136565-76-9 98%
    Lamotrigine N2-Oxide is a metabolite of the anticonvulsant Lamotrigine (HY-B0495).
    Lamotrigine N2-Oxide
  • HY-W654335
    Rivastigmine-d4 tartrate 98%
    Rivastigmine-d4 (tartrate) is deuterium labeled Rivastigmine (tartrate). Rivastigmine tartrate (ENA 713; SDZ-ENA 713) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM, 4.15 μM, respectively. Rivastigmine tartrate can pass the blood brain barrier (BBB). Rivastigmine tartrate is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease.
    Rivastigmine-d4 tartrate
  • HY-W654336
    (S)-Rivastigmine-d4 98%
    (S)-Rivastigmine-d4 is deuterium labeled Rivastigmine. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease.
    (S)-Rivastigmine-d4
  • HY-W680886
    6-APDB 152623-93-3 98%
    6-APDB is a class of monoamine neurotransmitter releaser and Monoamine Transporter modulator that exerts selective effects on human monoamine transporters and acts as a partial agonist at 5-HT2 family receptors. For NET, 6-APDB has an IC50 of 0.56 μM and a Ki of 18 μM; for SERT, it has an IC50 of 2.3 μM and a Ki of 23 μM; for DAT, it has an IC50 of 33 μM and a Ki of >30 μM, and affinity for rat and mouse TAAR1, with Ki values of 1.0 μM and 0.21 μM, respectively. 6-APDB inhibits norepinephrine and 5-HT reuptake, mediates the release of three types of monoamine neurotransmitters, shows a dose-dependent biphasic locomotor effect in mice, and fully substitutes the discriminative stimulus effect of MDMA. 6-APDB shows no significant cytotoxicity at high concentrations, and possesses empathogenic psychoactivity, potential hallucinogenic effects, and behavioral effects associated with intermittent abuse.
    6-APDB
  • HY-W681659
    Flutoprazepam 25967-29-7 98%
    Flutoprazepam (KB-509), a benzodiazepine drug, possesses anticonflict effect. Flutoprazepam (KB-509) prevents maximal electroshock, pentetrazol, and strychnine-induced convulsions in mice.
    Flutoprazepam
  • HY-W683876
    Desmethylmoramide 1767-88-0 98%
    Desmethylmoramide is structurally similar to known opioids. Desmethylmoramide has analgesic activity in rodents.
    Desmethylmoramide
Cat. No. Product Name / Synonyms Application Reactivity